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Trends in Cell Signaling Pathways in Neuronal Fate Decision

"Trends in Cell Signaling Pathways in Neuronal Fate Decision" ed. by Sabine Wislet-Gendebien
InTeOpP | 2013 | ISBN: 9535110590 9789535110590 | 366 pages | PDF | 24 MB


The objectives of this book were: 1) to offer a general understanding of signaling pathways underlying the capacity of differentiation of several types of stem cells into neurons, during the development; 2) to understand how those pathways are altered in pathological conditions; 3) to describe advances in cellular therapy that could be use to restore central nervous system dysfunction in pathological conditions.

Contents
Preface
Section 1 TGF-Beta Signaling and Neuronal Fate Decision
1 Role ofTGF-p Signaling in Neurogenic Regions After Brain Injury
2 Insulin/IGF-Signalling in Embryonic and Adult Neural Proliferation and Differentiation in the Mammalian Central Nervous System
3 The Role of Smad Proteins for Development, Differentiation and Dedifferentiation of Neurons
Section 2 Wnt Signaling and Neuronal Fate Decision
4 Wnt Signaling Roles on the Structure and Function of the Central Synapses: Involvement in Alzheimer's Disease
5 Roles of Wnt/p-Catenin Signaling in Controlling the Dopaminergic Neuronal Cell Commitment of Midbrain and Therapeutic Application for Parkinson's
6 Regulation of Cell Fate in the Brain by GSK3
Section 3 Neurotrophin and Neuronal Fate Decision
7 Neurotrophin Signaling and Alzheimer's Disease Neurodegeneration - Focus on BDNF/TrkB Signaling
Section 4 NF-K-b and Neuronal Fate Decision
8 NFkB Signaling Directs Neuronal Fate Decision
Section 5 Stem Cells and Signaling Pathways
9 Telencephalic Neurogenesis Versus Telencephalic Differentiation of Pluripotent Stem Cells
10 Regulation of Basal and Injury-Induced Fate Decisions of Adult Neural Precursor Cells: Focus on SOCS2 and Related Signalling Pathways
11 Neural Stem/Progenitor Cells for Spinal Cord Regeneration
12 Epigenetic Regulation of Neural Differentiation from Embryonic Stem Cells
13 Neural Fate of Mesenchymal Stem Cells and Neural Crest Stem Cells: Which Ways to Get Neurons for Cell Therapy Purpose?

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